Mycotoxins are one of the most immunosuppressive factors in animal diets. It is important to consider that consumption of certain mycotoxins, at levels that do not cause overt clinical mycotoxicosis, suppresses immune function and decreases resistance to infectious diseases. In this sense, mycotoxin adsorbents that are effective both in combating the damage caused by these metabolites and in protecting and supporting animal health are increasingly essential in the animal nutrition industry. The effect of mycotoxin adsorbents, with different compositions, on immunological parameters in broiler chickens challenged with mycotoxins has been evaluated. We used 300 broilers, distributed in a completely randomized design with four treatments and six replicates. Three mycotoxin adsorbents with different compositions were tested, which were added at 2.5kg/kg, in diets contaminated with 1.0 pp of aflatoxin + 50.0 ppm of fumonisin + 25.0 ppm of DON. Evaluation of a control diet without contamination (T1), contaminated diet + SIM – FIX HP (T2), contaminated diet + adsorbent A (T3), contaminated diet + adsorbent B (T4). On the last day of the experimental period, blood samples were collected from eight birds per treatment for the evaluation of phagocytosis by flow cytometry and the cecal tonsils were collected and the expression of pro-inflammatory interleukin 6 (IL 6) and anti-interleukin 10 determined. -inflammatory (IL 10) through quantification of gene expression by RT-qPCR. In the phagocytosis assay, a significant difference was observed between the control and T4 treatments, with a lower percentage of phagocytic monocytes for treatment 4, which also had the lowest IL-6 (pro-inflammatory) value. In the phagocytosis assay, a significant difference was observed between the control and T4 treatments, with a lower percentage of phagocytic monocytes for treatment 4, which also had the lowest IL-6 value. Among the evaluated adsorbents, YES FIX HP provided the highest average production of IL-10, which suggests a greater balance in the immune response of the animals to the challenge with mycotoxins, possibly contributing to the greater resistance of this group of animals to the main challenges faced in the field. and that require a response from the defense system.