Researches prove the efficiency of Yes microbiota modulators in the pet's immune system

Proper nutrition promotes more health, well-being and longevity for pets

We know that the relationships between tutors and pets are longstanding. These relationships were initially based on an animal as a working tool, but nowadays it is a relationship that involves a lot of feeling. It is a relationship based on wanting to provide your partner with health, well-being and longevity.

My name is Verônica Lisboa, I'm Research Coordinator at Yes, and I'm going to tell you about our results involving our improvers, our microbiota modulators, the Yes GOS and Yes Golf, on the intestinal health and immune parameters of dogs.

Today, we know that there are several ways to provide dogs, our pets, our companions, this health, well-being and longevity. One of those ways is through nutrition.

So, nutritionists and researchers have focused all their efforts so that food is not only a supplier of carbohydrates, vitamins, proteins, but that it can also contribute to the health and well-being of animals. Among these foods, these well-studied nutrients, we have prebiotics.

And what are these prebiotics?

They are food or substrates for good gut bacteria. We know that the intestine is colonized by a part of good bacteria and pathogenic bacteria. Prebiotics have the ability to be fermented, that is, to be food for good bacteria.

In this way, we are able to modulate the intestinal microbiota, providing a better balance between a colony of good, beneficial and desirable bacteria and pathogenic colonies. When fermented by good bacteria, they produce short-chain fatty acids. Examples of these important fatty acids: acetic acid, propionic acid and butyric acid.

When producing these acids in the acidic intestinal environment, there is a drop in the pH of the animal's intestine, that is: it becomes more acidic. Beneficial bacteria can survive, colonize and remain viable in an acidic environment. Pathogenic bacteria, on the other hand, do not have this ability.

So they cannot remain viable in acidic environments. This is also a way for us to provide this balance in favor of the beneficial microbiota. And when I talk about beneficial microbiota, let's take as an example two large groups that are well known: we have bifidobacteria and lactobacilli, which are good, desirable bacteria that colonize the animal's intestine.

And when we talk about pathogenic bacteria, as an example we also have known E. coli, Salmonella, Staphylococcus, which are those that we want to decrease in the animal's intestine.

Modulating the microbiota is a direct benefit of the prebiotic or microbiota modulator. But there are secondary benefits caused by ingesting these prebiotics.

Among these secondary benefits, we also have the immunomodulation of the immune system, that is, the defense of these animals against challenges, and then bacterial challenges, pathogenic challenges, fungi, challenges caused by stress.

So, these bacteria, when fermenting prebiotics, they produce substances that are able to interact with the animal's immune system, making it more prepared or more able to defend itself if necessary.

Thinking about this scenario, Yes brings the microbiota modulators to the animal. So we have our GutBio line, which is formed by Yes MOS, which is the mannanoligosaccharide. It has the property of being fermentable, too, but it has another benefit: it agglutinates pathogenic bacteria.

What does it mean to agglutinate?

“Agglutinate” means that it will prevent the pathogenic bacteria from colonizing the animal intestine, and we know that a premise for it to exert this pathogenicity is that it fixes itself in the animal's intestinal epithelium.

Since the MOS will be in contact with the pathogenic bacteria, it will bind to it and it will be excreted in the feces, thus not colonizing the animal's intestine. If she didn't colonize, she won't exert her pathogenicity. So, in addition to MOS being a microbiota enhancer, it also has this binding power over pathogenic gram negative bacteria.

In addition to Yes MOS, we have Yes FOS in our portfolio. YES FOS is a fructooligosacide. It is derived from sugarcane, and it is a substrate for other bacteria, especially for lactobacilli, which are a group of important bacteria that produce, among other substances, lactic acid. Lactic acid is extremely important, too, when it comes to an animal's immunity.

We also have Yes GOS, which is a galactooligosaccharide, which is a by-product, which is a by-product of the dairy industry. It is derived from whey permeate, and it also forms a substrate for good bacteria.

In the same way that lactobacilli have an affinity for fructooligosaccharides, the other beneficial group of bacteria, which are bifidobacteria, have a great affinity for fermenting galactooligosaccharides.

When we talk about pet nutrition, for dogs and cats, we have already very well established and studied the beneficial results of the action of MOS and FOS in the nutrition of these companion animals.

Our GutBio line, then, is formed by Yes FOS, Yes GOS and Yes MOS, as intestinal microbiota improvers. They modulate the microbiota by being fermented by good bacteria.

We also have, in this intestinal health line, Yes Golf. Yes Golf is a blend of intestinal microbiota improvers. So, it's a solution, a tool, that has benefits gathered from various modulators. Composing Yes Golf, we have: Yes MOS, YES GOS and Yes FOS, with the benefit of having, in this same tool, the beta glucan.

Beta glucan acts directly on the animal's immune system. So, with Yes Golf we were able to supply microbiota modulators and an immunomodulator. It's a tool, a solution that delivers many benefits.

We are passionate about science!

Founded in 2008, the YesSinergy® it combines animal welfare, food safety and sustainability to produce natural additives that replace antibiotics for animal health and nutrition. Since 2016, YES has been part of the Aqua Capital, investment fund aimed at companies in the agribusiness sector in Brazil and South America.